THE NALLUR B. RAMACHANDRA LABORATORY
Genetics and Genomics Lab- University of Mysore


 Dr. N. B. RAMACHANDRA

Principal Investigator 

Fellow of Indian Academy of Sciences (FASc.)

Chairman - Department of Studies in Genetics and Genomics

Chairman-BOS in Genetics and Genomics

Deputy Coordinator - UGC-SAP (CAS-1), DOS in Zoology (UG & PG)

Director- University of Mysore Genome Centre (UMGC)

http://umgc.uni-mysore.ac.in/       

 

From the last two decades, my lab has contributed to the understanding of the following

  • Genetics of Congenital Heart Disease which has revealed consanguineous marriages, chromosomal anomalies, and SNPs in GATA4, NKX2.5, CRELD1 as risk factors.
  • Identification of maternal grandmother age as a risk factor in more young mothers producing Down Syndrome in India.
  • Genetic analysis of asthma which has revealed parental consanguineous marriage and serum ICAM-1 association with asthma.
  • Identification of five new genes of dyslexia involved in dendritic spinal-plasticity through whole genome-wide copy-number scan.
  • Our work on human genotypic variation in Olfactory Receptor provides pieces of evidence for the complexity to the continuously occurring OR CNVs.
  • We have identified XTR region of Yp11.2 and Xq21.3 as new PseudoAutosomal Region3.
  • We have established global CNV map using a Genome-wide scan of CNVs in humans across 12 populations and established the burden of the same on coding genome with a special emphasis on miRNA regulation leading to phenotypic diversity.
  • Long range interracial hybridization experiments in Drosophila nasuta system have evolved many new stabilized cytoraces in 30 years which would take millions of years in nature that will provide evidence for “adaptive evolution of genome” due to “recombinational speciation” illustrating the power of evolution.
  • We have also induced and isolated second chromosome specific Indirect Flight Muscle mutants in Drosophila melanogaster which are involved in myoblast proliferation, myofibril-assembly, and function.

Currently,

  •      We work on genetics and genomics of complex human genetic diseases like Asthma, Autism and Parkinson's disease to elucidate the network on gene-gene, gene-protein and protein-protein interactions to identify and establish the disease-specific pathway and databases.   
  •    We have also focused on whole-genome sequencing of laboratory-evolved cytoraces to understand the adaptive evolution of genome in Drosophila as well as on whole-genome sequencing of pathogens such as Mycobacterium tuberculosis and Methicillin-resistant Staphylococcus aureus (MRSA).

LATEST UPDATES 

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OFFICE :

Department of Studies in Genetics and Genomics

University of Mysore, Manasagangotri

Mysuru-570 006, Karnataka, INDIA

 


PHONE:

0821- 2419781/ 888


EMAIL:

ramachandra@genetics.uni-mysore.ac.in

nallurbr@gmail.com