THE NALLUR B. RAMACHANDRA LABORATORY

Genetics and Genomics Lab- University of Mysore

Dr. N. B. RAMACHANDRA

Principal Investigator
Fellow of Indian Academy of Sciences (FASc.)
UGC-BSR Faculty Fellow - Department of Studies in Genetics and Genomics
Karnataka Science and Technology Academy (KSTA)
Chairman-Human Ethical Committee, Mysore Medical College and Research Institute
Consultant - Human Genetics Unit, All India Institute of Speech and Hearing, Mysuru
Professor(Hon.)- Sri Sathya Sai Institute University for Human Excellence, Kalaburagi
http://umgc.uni-mysore.ac.in/

For the last two decades, my lab has contributed to the understanding of the following

  • Genetics of Congenital Heart Disease which has revealed consanguineous marriages, chromosomal anomalies, and SNPs in GATA4, NKX2.5, CRELD1 as risk factors.
  • Identification of maternal grandmother age as a risk factor in more young mothers producing Down Syndrome in India.
  • Genetic analysis of asthma which has revealed parental consanguineous marriage and serum ICAM-1 association with asthma.
  • Identification of five new genes of dyslexia involved in dendritic spinal-plasticity through whole genome-wide copy-number scan.
  • Our work on human genotypic variation in Olfactory Receptor provides pieces of evidence for the complexity to the continuously occurring OR CNVs.
  • We have identified XTR region of Yp11.2 and Xq21.3 as new PseudoAutosomal Region3.
  • We have established global CNV map using a Genome-wide scan of CNVs in humans across 12 populations and established the burden of the same on coding genome with a special emphasis on miRNA regulation leading to phenotypic diversity.
  • Long range interracial hybridization experiments in Drosophila nasuta system have evolved many new stabilized cytoraces in 30 years which would take millions of years in nature that will provide evidence for “adaptive evolution of genome” due to “recombinational speciation” illustrating the power of evolution.
  • We have also induced and isolated second chromosome specific Indirect Flight Muscle mutants in Drosophila melanogaster which are involved in myoblast proliferation, myofibril-assembly, and function.
  • We have identified genomic variants in high-risk genes for Congenital Heart Disease (CHD), Autism Spectrum Disorder (ASD), Cardiovascular disease and multiple myeloma through exome sequencing.
  • Currently,

  • We work on genetics and genomics of complex human genetic diseases like Asthma, Autism and Parkinson's disease to elucidate the network on gene-gene, gene-protein and protein-protein interactions to identify and establish the disease-specific pathway and databases.
  • We have also focused on whole-genome and transcriptome sequencing of laboratory-evolved cytoraces to understand the adaptive evolution of genome in Drosophila.
  • We study Drosophila speciation and adaptation taking evolutionary genetics approach. This project is focused on understanding the role of Darwinian natural selection acting on key genes involved in speciation and adaptation.

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